vince_andrich’s BodyBlog

Nutrition and Supplement Strategies that Go BEYOND the €˜Perpetual PUMP’ for True Muscle Growth and Cellular Recovery

PART ONE

By Vince Andrich

You want the ability to get a “perpetual pump in any body part you train, every single time you walk into the gym, right? You are in pursuit of the almighty PUMP because you truly believe it holds the key to building more muscle size and strength, correct? You also believe that the magnitude of the pump you get in the gym is an indication that you’re on your way to less bodyfat and more defined muscles, true? Now, what if I said you were right and that the PUMP really was a reliable gauge of your bodybuilding progress? Well it is, but there seems to be a misunderstanding of sorts. You see, if you’ve been following this line of thinking €” that pump equals growth €” you must realize that the traditional mechanisms for accessing a perpetual pump, pale in comparison to a startling new breakthrough in bodybuilding chemistry. Don’t get me wrong, you will still learn about an integrated system that will allow you to attain a maximum pump, but you’ll discover that there is definitely more. This approach represents an entirely new way to look at the mechanisms for bodybuilding success €” one where the benefits are noticeable and, most importantly, permanent.

The Breakthrough is Not For Everyone
The techniques outlined in this article are not intended for everyone, although anyone can benefit. What I mean is simply this: you need to €˜come clean’ and be honest about your bodybuilding goals and how YOU plan to achieve them. Let me explain more. If you are on a sophisticated regimen of bodybuilding pharmaceuticals like growth hormone, testosterone, insulin and the like, your ability to get a pump in the gym should be simple. If this is your approach to bodybuilding, then the rest of this article is of no relevance to you. I am not an expert on bodybuilding drugs, but I do know enough to say that whenever I am working with an athlete who is ON, my traditional nutritional recommendations are not necessarily applicable. This is why my focus is to work with athletes who’s hormone levels are not off €” or all over €” the charts, and therefore do not undergo severe fluctuations. However, even if you choose to go to the “dark side and use bodybuilding drugs, which I do not suggest, you can’t stay on them long term. Eventually, if you want to have your health and a great body too, you’ll be seeking out “legal bodybuilding chemistry, like the information in this article.

Nitric Oxide Boosters and the Rise of the Almighty PUMP
The popular trend in bodybuilding supplementation these days is the use of Nitric Oxide (NO) boosters as a method for increasing your “pump while weight training. The use of nitric oxide supplements (NO is the acronym, for nitric oxide), has gained quite a following since they initially hit the bodybuilding scene around four years ago. I won’t go into the exact mechanisms associated with boosting nitric oxide, but the principle benefit appears to be vasodilatation. By improving vasodilatation, an athlete would experience increased blood flow from dilated blood vessels. As time goes on, more performance supplement companies are marketing various formulas as nitric oxide boosters, thereby dramatically increasing the popularity of the category.

The highly anticipated benefits associated with increasing nitric oxide levels were initially driven by multiple marketing campaigns and by at least one popular book. Many of the marketing claims for nitric oxide products became very similar to those of creatine. For example, fuller muscles, tighter pumps, gains in power and strength, and increased cell volume. As a result, these products were €˜granted’ nearly the same credibility as creatine, when it first hit the market. The hype for the nitric oxide products gave birth to what is now almost indistinguishable from the creatine category, and in fact, many of the most popular formulas include creatine as a major active ingredient.

I have no doubt that the most significant reason these products are in demand is because they are endorsed as a means for promoting massive pumps in the gym, increasing lean mass, enhancing fast twitch muscle, quicker recovery and improving strength, but the purpose of this article is not to dispute or justify these claims. Whether or not nitric oxide supplement claims hold up to the acid test of real-world training is an entirely different subject, so I’ll save it for another time.

What is The Pump?
In bodybuilding circles, the sensation of tight congestion, or swelling, of your muscles with blood during your weight training session is €˜The Pump’. Now, a weight trainer with any experience knows that if you lift a heavy enough weight, and don’t rest too long between sets, your working muscles will become swollen with blood. In scientific jargon, this is referred to as reactive hyperemia because it involves an increase in blood flow (i.e., hyperemia) in response (i.e., reactive) to the exercise stimulus.

Triggering the Osmotic Anabolic Signaling System
So, what’s the big deal with striving to attain what popular bodybuilding jargon refers to as a Super Pump? To be blunt, The Pump is the manifestation of many physique-altering benefits that are not visible to the eye. Ironically, what seems like such a foolishly vain aspect of bodybuilding to the uninformed is, in fact, an excellent means for judging your nutritional status, current anabolic/catabolic condition and measure of training recovery.

In essence, it appears that the magnitude of the PUMP you get in the gym can be traced back to multiple factors associated with muscle growth and recovery, and are intimately related to an intricate cellular swelling mechanism that modern scientific literature calls Osmotic Anabolic Signaling  (OAS). This phenomenon is at the heart of building new muscle year round, and retaining lean mass in the face of hypo-caloric dieting. To maximize this system requires attention to several “puzzle pieces, of which nutrition tops the charts.

Diet and Muscle Cell Dynamics
When you are well fed, i.e., carbohydrates are not restricted, your ability to get a pump should be pretty easy, even if your diet is not optimal. However, it has become increasing popular for weight trainers to follow a diet that carefully considers carbohydrate intake. The modern bodybuilding diet usually allows for 40-50% of your daily calories to come from carbohydrates. This number may increase for athletes who weight train for sports, which make it necessary for additional daily energy calories to be burned beyond those needed for the gym. Typically, carb intake is under strict control when an athlete wants to avoid gaining fat (this could be all year round), or must lose excess bodyfat for a wide range of goals including contest prep. For example, consuming less than 100 grams of carbohydrates is the standard level for a “low-carb day. If this level seems low, it is, but keep in mind these diets usually remove carbohydrate calories and make up the remainder of the daily calorie allotment from increases in protein and/or fat. The best low-carb diets put an emphasis on protein intake due to its ability to promote additional calorie wasting.

The underlying problem with excessive restriction of carbohydrate is that when training intensity is high (and of course intensity is key to keeping or increasing muscle size much less the PUMP), even 200 grams of carbohydrates per day for larger athletes is tremendously meager. Research has shown that a high-protein diet coupled with low-carbohydrate intake creates a metabolic environment called acidosis, which is not conducive to high intensity weight training , . In addition, weight training intensely while simultaneously reducing carbohydrates dramatically depletes stored energy in muscle (glycogen), and therefore we know that low-carb dieting cannot be followed for weeks on end.

Fortunately, most athletes realize that it is best to utilize carb depletion/cycling regimens rather than attempt to stay on reduced carbs for the entire length of their diet. That is, they follow a few days of low-carb eating (usually 2-3) and then allow themselves a day or so of “normalized feeding to drive the replenishment of glycogen so that training intensity can be maintained. The other benefit associated with this diet format is that the athlete enjoys maximum fat burning on low-carb days, and then when carbs are reintroduced in greater amounts, insulin is allowed to help maintain the desired anabolic state. Further, boosting carb intake at this point offers a mechanism to reinvigorate natural thyroid production €” often reduced when on low-carb diets €” for improved metabolic function.

Moreover, a consideration of importance, beyond the aspect of performance, is the anabolic effect of insulin secretion on muscle protein synthesis. Moderate carbohydrate intake at each meal should stimulate the proper insulin levels needed for maximum muscle protein synthesis. Over time depressed insulin secretion may halt any additional muscular progress.  Therefore, my approach to feeding for most of the year is to systematically eat a little less carbs than I need and more protein than I can use. This concept is fully explained in a booklet called ‘No Mistakes’ - The Nutrition Guide to Building Your Best Body Ever. I wrote this guide with my colleague Rob Thoburn, who is an absolute bodybuilding genius and now works for the forward-thinking sports nutrition company BSN.

Nutritional Clues Related to €˜OAS’
I’ve mentioned relative dietary concepts because at the end of the day, your nutritional status will ultimately become the €˜core’ to engaging OAS, and the PUMP you get in the gym. How much does nutrition have to do with OAS? Have you every wondered why your muscles are flat some days and on others full?  As you recall the muscle contains stored carbohydrates. Guess what?  For every carbohydrate gram you store an additional 2.7 grams of water!  Whenever you consume plenty of carbs, your muscle cells become saturated with them, and each carb pulls nearly 3 grams of water into a virtual anabolic Jacuzzi! Therefore, your muscles fill up like a balloon!  You can always tell how anabolic your nutrition is by how full your muscle cells are. As we touched on previously, when you are on a reduced-carb diet, your muscle cells become flat and your skin is loose, and doesn’t look very tight. The initial stages of this are common while dieting, because the athlete is simply low on carbohydrate stores in their muscle cells. However, in speaking with many advanced athletes if your muscle cells are left high and dry for too long, with nothing to hold water inside the cell, you will eventually chew up your hard-earned muscle.

So, this raises the question: Can you get a super pump in the gym while carb intake is low? In my opinion, the answer is no, probably not.
Keep in mind the pump is relative, and is can only be judged against your personal experience. But you will get a better pump when your carb intake allows for stored glycogen in your muscles to be roughly 50% of capacity, and your water intake is adequate. As a reference, adequate fluid intake for a 200-lb athlete is about 1-gallon of water, or 12, 8-ounce glasses. When it comes to gauging your stored muscle glycogen levels, then best assessment is the mirror, which we will discuss in detail in the next section.

Go Here for
PART TWO

http://blog.bodybuilding.com/vince_andrich/2006/10/25/osmotic-anabolic-signaling-part-ii/

The Next Frontier in Legal Fat Loss Pharmacology that

Goes BEYOND €˜Thermogenics’ for Rapid & Permanent Fat Loss

PART ONE

By Vince Andrich

Over the years, I’ve probably been asked more about getting ripped than about any other fitness-related topic. I’m totally cool with that because my focus has always been on the cosmetic aspects of nutrition and exercise. While some may balk at the idea of cosmetic fitness, it is my view that people are more likely to put forth the effort it takes to get the health benefits associated with fitness, if they are doing it the name of vanity. Arguably, improving your appearance seems to have more immediate “benefits than for example, improving heart health, making it a much more motivating pursuit. Ironically, what it takes to improve cosmetic fitness in fact delivers superior health benefits, but that’s another article all together.

Needless to say, the topic of getting ripped is an area that really intrigues me, and I’ve got more than a few theories that I’d like to elaborate on. But beforehand, we all need to get on the same page and understand that if you wanna get ripped €” if you really want to get lean €” there is no such thing as a free ride. Next, let’s agree that any serious “cutting regimen includes an eating strategy based on some type of macronutrient control and manipulation. The wide range of eating strategies includes everything from protein/carb cycling to simple calorie control, but for the sake of this conversation it doesn’t matter. Now, if you’re still with me, understand this: I believe that no matter what “diet you’re on, going beyond your previous best “muscle to fat ratio will eventually come down to a game of mental Russian roulette.

That’s right. Think about it! When you attempt to go beyond your normal limits in any endeavor the mind calls the shots. Those who’ve been there know what I mean. Like Christopher Walken’s character in the Deer Hunter, you take your diet to the point where each day, you roll the cylinder and see if you can escape the bullet in the chamber that will be your mental breaking point.

Don’t be confused; I’m not talking about a breakdown of mental motivation, that’s another discussion. I’m talking about improving your chances of diet success by tweaking the balance of your “mindspace through the use of what I like to call “Neuro Chemical Diet Warfare.

Engineering Irrational Minds To Prevail
I could be way off, but my opinion is that concentrations of neuro chemicals that can benefit dieters are scarcer, or simply less affective when the body is deprived. My reasoning? Well, it seems when deprived, the mind automatically obsesses on the exact thing you’re being deprived of……even if the obsession irrational. For example, I remember during those last weeks of contest dieting, the mere thought of being “allowed to eat anything “extra was always top of mind. I’d often say to myself; “maybe I screwed up my food journal and can eat another meal. Knowing full well that my food journal was always followed to the letter €” to the last morsel. So why would I begin this debate with myself? Sound familiar?

I know it has been written about many times before, but it’s worth mentioning again; dietary restrictions kick in untold years of programming that tells your brain that “you’re starving. So even if you really aren’t starving €” even if you have plentiful food within your reach €” your mind becomes irrationally obsessed with eating.

Quite possibly our starvation radar goes off even sooner when we are simply attempting to go below a certain level of bodyfat, often called the “set point. This effect is most pronounced and extremely exaggerated when restricting water, say for a bodybuilding contest or making a weight class. All you can think about is liquids, or something wetter than your dry like the Sahara desert mouth! Seriously, until you REALLY restrict water intake you just don’t know how good a thimble of water or ice cube sounds. These thoughts take precedence over everything. No doubt food (and more so, water) top the charts for survival and so getting an extra edge in this arena will be tough, but certainly worthwhile. IMO, this survival or pleasure mechanism can be overridden.

Why? Because it happens naturally in everyday life, and is most easily seen when a person either falls in love or they have issues with their love interest such as the possible break-up of a marriage/relationship. Simply stated, the desire for food has been known to significantly change whenever a person experiences something very pleasant or unpleasant.

These are just a few of the reasons I believe tweaking your supply and balance of serotonin, epinephrine, norepinephrine and dopamine is seriously a BIG DEAL when it comes to fat loss. No matter how experienced you are as a dieter, understanding the power of these neurochemicals holds the key to suspending or minimizing those unforgettable feeding signals that are hardwired into our biology.

Talking Points, Theories and Situation Analysis
The talking points set out below outline a possible prototype for future neurochemical diet strategies. Take these points for what they are; theories, but they are theories with the added insight of what really goes on inside the mind of a serious dieter. Some experts in the applicable fields will probably cringe, at least in places, because inevitably, some of my pop neuroscience is simplistic to the point of perversion. But I am not here to cure mental illness; but I do want to give YOU a mental advantage so you can lose more fat with less pain and suffering.

So that’s all the apologies I’ll make. I feel the subject matter is relevant and in the near future will be key a factor in any high level athlete or serious dieter’s fat loss plan. It is almost insane NOT to realize, quite intuitively that is, that the mind is the ultimate decision maker and all diets succeed or fail because of these decisions.

Willpower and Anti-Food Psychotropics
There is a whole host of psychotropic players that can affect food intake, but for the most part your brain levels of two key neurochemicals €” serotonin and dopamine €” seem to be most notable. The problem is that when it comes to making neurochemical connections to food intake, not everyone has the same wiring, and thus, there is not one off-the-shelf solution. Take serotonin for example; this neurochemical has been linked to carbohydrate cravings and is, in fact, released in response to eating carbohydrates. This is why dieters who want to naturally increase their brain levels of serotonin often take the supplement 5-HTP, a precursor to serotonin. The simple reasoning for increasing serotonin in the brain would be to reduce or delay your carbohydrate cravings. Put another way, your mind knows that eating carbs will eventually lead to the release of -serotonin, but if brain levels are “artificially adequate (through supplementation) your cravings might be minimized. On the surface this seems to be a great idea for low-carb dieters or those with heavy carb cravings.

Too bad it’s not that simple

Let’s take a look at some popular drugs that work on serotonin. It is well established that many people who use Prozac®, a selective serotonin reuptake inhibitor (SSRI), eat less and therefore can lose weight (although in some cases weight gain does occur). In contrast, Paxil®, another brand name SSRI, lists weight GAIN, not LOSS, as a side effect. In fact, I’ve spoke to many people who use Paxil and swear it is the cause of their weight gain. Now, it can be argued that the two SSRI compounds listed above are similar, but not exactly the same. However, it would seem that inhibiting the reuptake of serotonin would result in many of the same side effects or benefits. But it doesn’t always work that way. Something else must be going on.

The answer may be found in a study comparing the effects of fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft®), citalopram (Celexa©) and fluvoxamine (Luvox®) on extracellular concentrations of serotonin, dopamine, and norepinephrine in the prefrontal cortex of the brain. In this study, only fluoxetine (Prozac) showed robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. This simple difference might explain why Prozac could be a better drug for dieters. Of course this study doesn’t take into consideration what happens when you’re faced with dietary “restrictions.

Keep that thought:.

On the flip side, dopamine, a naturally produced neurochemical, functions as a neurotransmitter that activates dopamine receptors. Dopamine is also a neuro-hormone released by the hypothalamus. Dopamine is a precursor to epinephrine (adrenaline) and norepinephrine (noradrenaline) and is part of the catecholamine family, which plays a key role in releasing energy from fat and inhibiting fat storage. So, maybe we should just find a way to crank up the dopamine, right?

Well, take a look at this:

One drug affects dopamine and IMO, deserves much attention when it comes to dieting. The drug is Bupropion (amfebutamone), which is better known by the brand names Wellbutrin and Zyban.

I’m fascinated because the chemical is both a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor. Also, Bupropion has only a small effect on serotonin reuptake. Not surprisingly it is similar in structure to the stimulant cathinone, and to phenethylamines in general. It is a chemical derivative of diethylpropion, an amphetamine-like substance that is prescribed as an appetite suppressant. Pretty, cool so far, right?

For an athlete looking to get ultra ripped however, we want a reduction in appetite, not amphetamine induced anorexia that will grind up our mind and muscle and spit it out. You see if you flip the dopamine switch on high and break off the knob, you’ll be headed for a downhill spiral. This is because the closer you chemically get to amphetamines such as methamphetamines or cocaine, you beat on your dopamine system to the point where the desired signal is always ON and the neurotransmitters are not recycled. The net result is that dopamine gets severely depleted and the user becomes mentally addicted and in no condition to positively alter body composition.

The good news is that when dopamine rises to higher ranges in an intermittent fashion, our body handles the increase by engaging dopamine transporters (DAT’s) to remove excess dopamine from the receptor, effectively ending the signaling of the neurotransmitter and recycling the transmitter. So a transitory boost in dopamine levels when food cravings are imminent could be a very useful appetite suppressor. For sure it seems any positive neurochemical diet protocol would require the availability and proper recycling of serotonin and dopamine. Coincidently, Bupropion is also used to for smoking cessation, and since people who quit smoking seem to gain weight, there must be another food connection. So what’s the big deal with smoking?

Stay tuned for PART TWO