Detection of bumetanide in an over-the-counter dietary supplement
| J Anal Toxicol. 2007 Nov-Dec;31(9):601-4.
Detection of bumetanide in an over-the-counter dietary supplement. Hoggan AM, Shelby MK, Crouch DJ, Borges CR, Slawson MH. Bumetanide is a loop diuretic used clinically to treat heart failure, acute renal failure, high blood pressure, and edema. However, diuretics may also be used by athletes as masking agents and to decrease weight. Taken as masking agents, diuretics increase urine production and decrease urinary concentrations of banned performance-enhancing agents, such as anabolic steroids. StarCaps is an over-the-counter dietary supplement marketed as a diet aid. The manufacturer claims that the product contains only natural cleansing agents and emphasizes that it is free from traditional appetite suppressants such as sympathomimetic amines. However, no such disclaimer is made concerning diuretic agents. A single StarCaps capsule was administered to two male and two female volunteers, and their urine specimens were collected at discrete intervals (2, 4, 8, and 12 h) post administration. The specimens were analyzed by a high-performance liquid chromatography-mass spectrometry quadrupole (HPLC-MS) method, and bumetanide was detected in all specimens (4.6 to 351.3 ng/mL). Adjusting the bumetanide concentrations for creatinine content did little to normalize the excretion profiles. Bumetanide was also detected in the StarCaps capsules at concentrations approaching therapeutic doses. HPLC-quadrupole-time-of-flight mass spectrometry was used to confirm the presence of bumetanide in the urine samples and StarCaps capsules. The results showed that unregulated dietary supplements may put consumers at risk for unwitting consumption of prescription medications, and that it is possible for athletes to inadvertently test positive for bumetanide and face disciplinary actions. |
Bumetanide is often compared to furosemide (Lasix) in terms of effectiveness to fight edema and are part of the most powerful family of duiretics. You should know that bumetanide is actually considered anywhere from 15 to 100 times more potent than furosemide. What truly disgusts me about this is that by simply taking an NSAID with this you can cause kidney failure or an extreme state of dehydration requiring emergency treatment. GOOD JOB!!!!!
