Creatine Ethyl Ester…Reviewing the Literature
Creatine Ethyl Ether James D. Mold, Robert C. Gore, Joseph M. Lynch, E. J. Schantz. J. Am. Chem. Soc.; 1955; 77(1); 178-180.
Creatine ethyl ester is merely creatine monohydrate with an added ester attached to make the creatine molecule more lipopholic. In theory, this would make the absorption more efficient and possibly would require less CEE to serve as an ergogenic aid.
Personally, I have used both CEE and monohydrate with great success. However, the recomended doses of CEE (2.5 grams) never seemed to have the same effect as the recommended dose of monohydrate (5.0 grams). To me this seemed a little odd considering the claims of most CEE products. When I started to experiment with higher doses of CEE (5 grams) I noticed similiar effects to that of monohydrate at the equivalent dose. Something wasn’t adding up here.
Upon further reading on monohydrate, because no ethyl ester studies exist, I came across one that studied the physiological differences between monohydrate responders and non responders. This intrigued me because it actually shows that monohydrate isn’t inefficient given a certain set of physiological values with regards to pre-existing creatine and phosphocreatine levels in muscles, muscle fiber cross-sectional areas (CSA), the prevalanace of type II muscle fibers, and the amount of fat free mass.
Type II muscle fibers are also called fast twitch muscle fibers. Olympic sprinters may have up to 80% fast twitch fibers while a marathon runner may have up to 80% type I fibers (slow twitch). Both fiber types produce the same force but type II can fire more rapidly, hence the name fast twitch. Based on the the study I was referring to it appears those with a high type II fiber % respond well to creatine monohyrate and much more efficiently to those with a type I fiber %.
Also, it appears that those with larger muscle fiber (CSA) and fat free mass percentages are also better monohydrate responders. This means that if you have a high bodyfat percentage you might not respond well to monohydrate or if you have low muscle mass. Also, if you have smaller muscles in general you might not respond well.
For someone like myself, I do have a high percentage of fat free mass and therefore I respond well to creatine monohydrate. Also, I require the same amount of CEE to have the same ergogenic effects as monohydrate. I feel some companies have been pushing CEE a little too hard and have been addressing some of it’s shortfalls for those who might not respond well, like me, by telling the consumer to take another dose.
It is my recommendation that any consumer out there interested in creatine supplementation try using the more basic form of creatine first, which is monohydrate. It is the only form of creatine that has been studied extensively and proven. CEE is a good choice for those who don’t fit the physiological criteria stated above, however for general purposes, it is not “better” than monohydrate as many companies would lead you to believe.
Bizzarini E, De Angelis L. Is the use of oral creatine supplementation safe? J Sports Med Phys Fitness. 2004 Dec;44(4):411-6.






March 24, 2007 at 9:13 pm
*sigh*
and i’m usually really good with this stuff… my brain is on PAUSE… i swear…
i had to read that like 5 times to get it….
March 25, 2007 at 1:54 pm
Great article DES! If you would like to write articles for my website (keeping in mind I like things in layman’s terms) let me know!
After reading that, I think I made a good choice personally not taking creatine mono (my bf percentage is about 26 right now).
March 26, 2007 at 6:43 am
Nice advice Des! I was also taking an increased amout of CEE until my doctor freaked about my creatinine level of 3.4 mg/dL after my last physical. I had just taken my second dose of CEE aftter my morning workout. It has since returned to normal. I’m going to go with Size On Tabs for my next creatine sup.
January 11, 2008 at 10:38 am
THANK YOU BROTHER FOR THE ADVICE. I WAS JSUT TRYING TO FIGURE OUT WHICH TYPE OF CREATINE WAS THE BEST AND WHICH ONES ARE FILLED WITH PROPAGANDA…
RESPECTFULLY.