The Clinical Evidence to Support Creatinol-O-Phosphate’s Safety
I feel the following question deserved a lengthy answer:
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Originally Posted by zergling
One last thing, do you have any info on the safety of long-term use of creatinol-o-phosphate?
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One of the major flaws I have an extreme disdain for in the supplement industry are the use of compounds that have never had any clinical research to support their efficacy. I know most companies will cry that it’s not cost effective and they do have a valid point. However, clinical evidence is a broad step in securing the freedom to choose supplements long into the future.
Fortunately, there is strong clinical evidence which negates any potential criticisms for Aplodan’s (creatinol-o-phosphate) safety. I’ll give you a direct quote from a metastudy summarizes a very large body of research involving dogs, rats, guinea pigs, and rabbits:
| An interesting aspect of COP is it’s excellent therapeutic index, and the absolute absense of side effects, which have invariably been noted in pharmacological, toxicological, and clinical investigations |
Now I can imagine most of you are wondering how this pertains to use humans. To put it bluntly, I personally loathe seeing only animal models being used to support the efficacy of compound in a supplement. While some serve as a great reference, it is still always best to have actual clinical evidence derived from testing on actual human subjects. Fortunately, Aplodan has that too. Here is another direct quote:
| These observations and the fact none of the other parameters changed even at the highest COP dosage, lead the authors to conclude that COP is very well tolerated by the body and possesses an uncommon clinical safety. |
As both of the direct quotes of the studies indicate, COP is a very safe compound. My only digression is that all the long term studies were conducted in the animal models (480 days) and not human models (14 days). However, given the strong parallels across all the studies involving the use in humans and animals, it is very clear to me that this is a very safe compound for long-term use.
1. Marzo A, Ghirardi P. Pharmacological and toxicological properties of creatinol O-phosphate. A review.Arzneimittelforschung. 1979;29(9a):1449-52.
2. Melloni GF, Minoja GM, Lureti GF, Merlo L, Pamparana F, Brusoni B. Acute clinical tolerance of creatinol O-phosphate. Arzneimittelforschung. 1979;29(9a):1447-9.
