Creatinol-o-phosphate: Examining The Clinical Evidence
As promised, I have been extensively pouring over some of the old research involving the compound creatinol-o-phosphate. Much of the supporting research is either in Italian or German which is rather dissappointing. Based on citations in some of the studies which have been translated into English I can say we should be able to draw some fairly detailed conclusion as to how this compound improves performance.
Luckily, a lot of the research that published in Arzneimittel Forschung, which is German for “Drug Research,” was readily available to me after some lengthy searches. Via e-mail, I had the volume from 1979 pulled and headed out a few hours later to have a look at it. Off to the Ebling Library of Health Science I went. Admittedly, I was a little excited because this was a place I had never ventured before while in school.
When I first arrived and was handed the olive green volume I was a little worried. When I opened it up to the table of contents everything was in German. SHIT! I really thought I was screwed but fortunately when I turned to the section dedicated to creatinol-o-phosphate it was in English, so off to the copiers I went.
After copying about 50 pages of material I began the daunting task of learning everything about the first theoretical origins of COP in 1928 all the way through to the clinical trials held in the 1970’s. On the surface, all the research appeared very positive. I was impressed by the fact clinical trials were conducted on humans, which nowaday seems far and few between when it comes to documented evidence supporting the efficacy of a supplement.
Unfortunately, in skimming the related studies I failed to notice one VERY important clinical trial listed in bibliography of the this study:
Preliminary report on electrophysiological effectiveness of creatinol O-phosphate (COP) in human subjects. Arzneimittelforschung. 1979;29(9a):1491-4.
The clinical trial in question was:
Curr Ther Res Clin Exp. 1975 Jun;17(6):531-4. Creatinol O-phosphate (COP) and muscular performance: a controlled clinical trial Nicaise J.
As you can infer from the title this is very pertinant to our discussion to gain important insight into understanding the mechanisms. From an anecdotal standpoint, Aplodan does appear to be a good ergogenic and performance enhancing compound. However, I want to gain a better understanding of how it effects MG2+ depletion, Ca2+ influx, O2 utilization, and it’s ability to reduce cell membrane hyperpermiability. These appear to be the underlying mechanisms that gives Aplodan (COP) its legs to stand on as an effective supplement. You can’t just use ads as proof something works.
I’ll be heading out tomorrow to receive this last article and hopefully it will be my last. I love to understand the mechanisms by which exotic supplements “work” but also don’t want to miss the Badgers kick the Indiana Hoosiers’ arses on their home court. Final Four here we come!
February 1, 2007 at 1:31 pm
Now where was that t-shirt when my girls were babies??? ROFLMAO You rock.