Grape seed extracts and estrogen modulation.
One of the many benefits of grape seed extract is its ability to modulate estrogen biosynthesis. It achieves this capability via inhibiting a specific enzyme referred to as aromatase. Aromatase is an enzyme responsible for converting androgen substrates to estrogen.
The high levels of procyanidin dimers, especially the B dimers, found in grape seed extracts have been shown to be potent inhibitors of aromatase. Since aromatase is highly expressed in breast cancer tissue compared with normal breast tissue, data from both in vitro and in vivo studies suggest that grape seed extracts can act as chemopreventive agents against breast cancer by suppressing in situ estrogen biosynthesis.
Reference:
Kijima I, Phung S, Hur G, Kwok SL, Chen S. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun 1;66(11):5960-7.
Eng ET, Ye J, Williams D, Phung S, Moore RE, Young MK, Gruntmanis U, Braunstein G, Chen S.Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Res. 2003 Dec 1;63(23):8516-22.
Post by: Hypertrophik
May 30, 2008 - 10:32 am MDT at 10:32 am
my dad takes the stuff , but he takes it to control his yeast infection caused by Candida