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BrettCorless's Stats for MHP T-Bomb II
Created:11/29/2007
Last Modified:11/29/2007
Total Comments:0



MHP T-Bomb II

This is an excerpt from a paper I did on this supplement for a college class. I would recommend the supplement to those no younger than 25, as it will probably do nothing for you unless your test levels have started to decrease.
Ingredients

Five Phase Hormone Optimizing Blend: 903 mg
Tribulus terrestris
Fenugreek
Tongkat ali
Red clover extract
Chrysin
Kudzu root
Avena sativa
Zinc
Stinging nettle leaf
Beta siterol
Pygeum africanum extract
Saw palmetto berry extract
DIM (diindolymethane)
Bioperine® (black pepper extract)

2nd Messenger Hormone Amplifiers Receptor Signal Transduction: 625 mg
Flaxseed

Glycine
L-arginine
magnesium oxide
DL-malic acid
L-methionine
Cordyceps
NADH
dipotassium phosphate

Other Ingredients: Dicalcium Phosophate, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silica and White Film Coat Ingredients (Hypromellose, Enteric Film Coat Ingredients (hydroxypropyl methylcellulose phthalate, Hydroxypropylcellulose, Polyethylene Glycol, Titanium Dioxide)

However, the product does not give an exact amount of how much of each ingredient is included.

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These are the Claims made on Bodybuilding.com’s website, found here:
http://www.bodybuilding.com/store/mhp/t2.html

1. Increases Your Natural Production of Testosterone by 400%
2. Cripples SHBG and Increases “Free Testosterone”
3. Stops Testosterone to Estrogen Conversion
4. Blocks Estrogen Receptors
5. Lowers the Conversion of Testosterone to DHT

Here are the ingredients in groups of what they are supposed to do (from what I was able to research at the time):

Increase Natural Production of Testosterone
Tribulus Terrestris
Fenugreek
Avena Sativa (by supporting nervous system)
Tongkat Ali
DIM
Cordyceps

Bind to SHBG
Stining Nettle
Pygeum africanum extract

Stop Conversion to Estrogen or Block Estrogen Receptors
Red Clover Extract
Flaxseed
DIM

Lower Conversion of Testosterone to DHT
Beta Sitosterol
Zinc
Saw Palmetto

Increase Bioavailability
Bioperine

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The theory behind the product revolves mostly around Tribulus Terrestris extract. It should be able to increase luteinizing hormone (LH) which can then be converted into serum free-testosterone (T). 2

In an article titled, Tribulus Terrestris Update, by Richard B. Kreider, PhD., he gives a brief history of the supplement and also the theory behind its mechanism:

Tribulus terrestris is a plant (also known as puncture weed/vine or caltrops) that is mainly grown in sandysoil environments. It produces a fruit that is protected by a spiny burr. The extract from the fruit has been used in herbal medicine as a diuretic, for colic pains, and to fight hypertension and hypercholesterolemia

He goes further on to say:

The active agent in Tribulus is believed to be protodioscin. Protodioscin is a precursor to dehydroepiandrosterone (DHEA). As you may know, DHEA and androstenedione are precursors to testosterone. As one ages, androgen levels decline. Therefore, DHEA and androstenedione supplementation have been theorized as a means of naturally increasing testoserone levels particularly in older individuals. Although Tribulus is a precursor to DHEA, Tribulus is believed to indirectly affect testosterone levels by stimulating the release of leutinizing hormone (LH). LH serves to stimulate the natural production of testosterone. Theoretically, moderately increasing testosterone availability during training may promote greater gains in strength and muscle mass.

The combination of all ingredients, if all of them work as stated, would be a logical combination. If one is able to increase production of LH or T, keep it from binding to SHBG or from converting into estrogen or DHT, and make the ingredients more bio-available so that they work better, there would be a significant increase in testosterone and therefore, it should allow for gains in lean muscle mass and strength.

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Scientific Support

Most of the ingredients have some backing in science, either studies done in vitro or on animals. However, most ingredients lacked any human studies.

Most of the studies that did show a positive effect were done on rats. 4, 5 The few human studies that have been done have been either inconclusive or showed no effect on testosterone production. 6, 7, 10, 11, 13 One article stated that the move towards using Tribulus Terrestris came from studies done in Bulgaria that were translated into English. It states that the results should be regarded with caution. 8

This particular product has not undergone clinical testing itself, only the individual ingredients. 12, 14, 15, 16

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Safety

In most studies that have been done on tribulus in humans, there have not been any serious side effects nor toxicity. More research is needed however.

There is the possibility of some side effects due to increased T and LH production if they are converted to estrogen or DHT.

As previously mentioned however, there is a warning label that says the following:

Consult with your physician before using this product. Do not take this product if you have a medical condition including, but not limited to, diabetes, heart disease, psychological disorder, prostate hypertrophy or hormonal abnormalities. Consult with your physician if you are taking antidepressants, MAO inhibitors, or other prescription drugs. This product should not be used by women or males under the age of 18.

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Dosage: A serving size is 3 tablets. You are to take a serving in the morning and a serving at night. There are 56 servings per bottle, which, if used as directed, would give you 28 days worth.

The studies that have been done on tribulus usually had about 10-25 mg per kilogram of bodyweight or 750 mg/day. The product does not give an exact amount of how much of those herbals are in each serving.

Price: The price from the company would be $79.99 per bottle. At this price the consumer is not getting a very good deal. For the effect that it may give, the price is extremely steep. Bodybuilding.com has it priced at $48.99.

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References

1. http://www.bodybuilding.com/store/trib.html
2. Bahrke M, & Yesalis C (2002). Performance-Enhancing Substances in Sport and Exercise. Sheridan Books Inc: Pennsylvania.
3. Wu WH, Kang YP, Wang NH, Jou HJ, Wang TA. (2006). Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women. Journal of Nutrition, 136(5): 1270-5.
4. Gauthaman K, Ganesan AP, Prasad RN. (2003). Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model. Journal of Alternative Complementary Medicine. 9(2): 257-65.
5. Gauthaman K, Adaikan PG, Prasad RN. (2002). Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Science. 71(12): 1385-96.
6. Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, Jackson DA, King DS (2001). Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men. J American College of Nutrition. 20(5): 520-28.
7. Antonio J, Uelmen J, Rodriguez R, Earnest C. (2000). The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males. International Journal of Sport Nutrition and Exercise Metabolism. 10(2): 208-15.
8. Bucci LR. (2000). Selected herbals and human exercise performance. American Journal Clinical Nutrition. 72(2): 624S-36S.
9. Jameel JK, Kneeshaw PJ, Rao VS, Drew PJ. (2004). Gynaecomastia and the plant product “Tribulis terrestris”. Breast 13(5): 428-30.
10. Brown GA, Vukovich MD, Reifenrath TA, Uhl NL, Parsons KA, Sharp RL, King DS (2000). Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 10(3): 340-59.
11. Neychev VK, Mitev VI (2005). The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. J Ethnopharmacol 101(1-3): 319-23.
12. THE JOURNALOF ENDURANCE. August 2004 7
13. Kohut M, Thompson J, Campbell J, Brown G, Vukovich MD, Jackson DA, King DS (2003). Ingestion of a Dietary Supplement Containing Dehydroepiandrosterone (DHEA) and Androstenedione Has Minimal Effect on Immune Function in Middle-Aged Men. Journal of the American College of Nutrition 22(5): 363-371.
14. http://www.bodybuilding.com/store/avena.html
15. Ang HH, Cheang HS (2001) Effects of Eurycoma longifolia jack on laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats. Arch Pharm Res 24(5): 437-40.
16. Ng SS, Figg WD (2003). Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice. Anticancer Res. 23(5A): 3585-90.
17. Le HT, Schaldach CM, Firestone GL, Bjeldanes LF (2003). Plant-derived 3,3′-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem. 6;278(23): 21136-45. Epub 2003 Mar 27.
18. Carani C, Salvioli V, Scuteri A, Borelli A, Baldini A, Granata AR, Marrama P (1991). [Urological and sexual evaluation of treatment of benign prostatic disease using Pygeum africanum at high doses] Arch Ital Urol Nefrol Androl. 63(3): 341-5.
19. http://www.bodybuilding.com/store/flax.html
20. Hsu CC, Huang YL, Tsai SJ, Sheu CC, Huang BM (2003). In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci. 73(16): 2127-36.

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